3D collagen scaffold for 3D cell culture.

LYOPOR is 3D porous cell substrate (3D collagen scaffold), whose base consists of collagen type I suitable for testing the behavior of a wide range of cells in their natural 3D environment mimicking extracellular matrix. LYOPOR is suitable for cell culture, (bone) tissue engineering, regenerative medicine, wound healing etc.

Lyopor 3D Collagen Scaffold

The LYOPOR is a long time-tested 3D porous cell substrate, whose base consists of collagen type I suitable for testing the behavior of a wide range of cells in their natural 3D environment mimicking extracellular matrix.

Lyopor

Pure

Ready to use bio-mimicking 3D collagen scaffold for real 3D cell cultivation.

Lyopor

Hydroxyapatite

Nature-inspired collagen-hydroxyapatite 3D-scaffold for 3D cell cultivation of hard tissues.

Lyopor

Chitosan

Collagen scaffold with chitosan for 3D cell cultivation.

Lyopor

Customization

The basic variants of 3D cell substrate/scaffold LYOPOR can be modified according to the needs of the client application.

Publications and Science

Selected papers published on LYOPOR for in-vitro and in-vivo applications

  1. Prosecka, E.; Rampichova, M.; Litvinec, A.; Tonar, Z.; Kralickova, M.; Vojtova, L.; Kochova, P.; Plencner, M.; Buzgo, M.; Mickova, A.; Jancar, J.; Amler, E.: Collagen/hydroxyapatite scaffold enriched with polycaprolactone nanofibers, thrombocyte-rich solution and mesenchymal stem cells promotes regeneration in large bone defect in vivo. J. BIOMED. MAT. RES. PART A, 2015, 103(2), 671-682.
  2. Prosecka E.; Rampichova M.; Vojtova L.; et al. Optimized conditions for mesenchymal stem cells to differentiate into osteoblasts on a collagen/hydroxyapatite matrix. J. BIOMED. MAT. RES. PART A, 2011, 99A (2), 307-315.
  3. Plánka, L.; Nečas, A.; Crha, M.; Proks, P.; Vojtová, L.; Gál, P.: Treatment of a Bone Bridge by Transplantation of Mesenchymal Stem Cells and Chondrocyted in a Composite Scaffold in Pigs. Experimental Study. ACTA CHIRURGIE ORTHOPAEDICAE ET TRAUMATOLOGIE CECHOSLOVACA, 2011, 78(6), s. 528-536.
  4. Nečas, A.; Proks, P.; Urbanová, L.; Srnec, R.; Stehlík, L.; Crha, M.; Raušer, P.; Plánka, L.; Amler, E.; Vojtová, L.; Jančář, J.: Radiographic assessment of implant failures of titanium 3.5 LCP vs. 4.5 LCP used for flexible bridging osteosynthesis of large segmental femoral diaphyseal defects in a miniature pig model. ACTA VETERINARIA BRNO. 2010, 79(4), s. 599-606.
  5. Nečas, A.; Proks, P.; Urbanová, L.; Srnec, R.; Stehlík, L.; Crha, M.; Raušer, P.; Plánka, L.; Janovec, J.; Dvořák, M.; Amler, E.; Vojtová, L.; Jančář, J.: Healing of large segmental bone defect after implantation of autogenous cancellous bone graft in comparison to hydroxyapatite and 0.5% collagen scaffold combined with mesenchymal stem cells. ACTA VETERINARIA BRNO. 2010, 79(4), s. 607- 612.
  6. Nečas, A.; Plánka, L.; Srnec, R.; Crha, M.; Hlučilová, J.; Klíma, J.; Starý, D.; Křen, L.; Amler, E.; Vojtová, L.; Jančář, J.; Gál, P.: Quality of newly formed cartilaginous tissue in defects of articular surface after transplantation of mesenchymal stem cells in a composite scaffold based on collagen I with chitosan micro- and nanofibres PHYSIOLOGICAL RESEARCH. 2010, 59(4), s. 605-614.
  7. Jančář, J.; Vojtová, L.; Nečas, A.; Srnec, R.; Urbanová, L.; Crha, M.: Stability of collagen scaffold implants for animals with iatrogenic articular cartilage defects ACTA VETERINARIA BRNO. 2009, 78(4), s. 643-648.
  8. Filova, E.; Burdikova, Z.; Rampichova, M.; Bianchini, P.; Capek, M.; Kostakova, E.; Amler, E.; Kubinova, L.: Analysis and three-dimensional visualization of collagen in artificial scaffolds using nonlinear microscopy techniques. JOURNAL OF BIOMEDICAL OPTICS, 2010, 15 (6), Article Number: 066011
  9. Planka, L.; Srnec, R.; Rauser, P.; Stary, D.; Filova, E.; Jancar, J.; Juhasova, J.; Kren, L.; Necas, A.; Gal, P.: Nanotechnology and mesenchymal stem cells with chondrocytes in prevention of partial growth plate arrest in pigs. BIOMEDICAL PAPERS-OLOMOUC, 2012, 156 (2), s. 128-134. ISSN: 1213-8118.

Conference prezentations

  1. Prosecka, E; Rampichova, M; Lytvynetse, A; Vojtova, L; Uhlik, J; Vajner, L; Kochova, P; Tonar, Z; Plencner, M; Buzgo, M; Kova, Am; Amler, E.: 3d smart composite collagen/ha/pcl/prp scaffold seeded with mesenchymal stem cells for bone regeneration in vivo, INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. 2011, 34(8) Special Issue: s. 664-664
  2. Prosecka, E.; Rampichova, M.; Lytvinets, A.; Vojtova, L.; Tonar, Z.; Kralickova, M.; Kochova, P.; Plencner, M.; Buzgo, M.; Mickova, A.; Benesova, J.; Amler, E.: 3D functionalized collagen/hydroxyapatite scaffold seeded with MSC for bone defect regeneration in vivo. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2012, s. 37-37.
  3. Prosecká E., Rampichová M., Litvinec A., Vojtová L., Kochová P., Tonar Z., Plencner M., Buzgo M., Amler E. Kolagen/Hydroxyapatitový nosič funkcionalizovaný nanovlákny z Polykaprolaktonu, Trombocytárním koncentrátem a mesenchymálními kmenovými buňkami pro regeneraci kostních defektů in vivo. 4th international conference of Bioimplantology, 28-29 of April 2014, Brno, Czech rebubilc. SBORNÍK ABSTRAKT, 2014, s. 41-41.
  4. Uhrová L., Abdel-Latiff Abdel-Mohsen, Vojtová L., Jančář J.: Charakterizace a in vitro testování Kolagen/polysacharidových kompozitních skafoldů pro medicínské aplikace. 4th international conference of Bioimplantology, 28-29 of April 2014, Brno, Czech rebubilc. SBORNÍK ABSTRAKT, 2014, s. 33-33.
  5. Vojtová, L.; Jančář, J.; Nečas, A.; Plánka, L.; Crha, M.; Proks, P.; Gál, P. Regenerace růstové ploténky resorbovatelným biopolymerním kompozitem s kmenovými buňkami a chondrocyty. IV. CELOSTÁTNÍ KONFERENCE BIOIMPLANTOLOGIE 2012. Brno: Společnost pro Bioimplantologii, 2012. S. 40-40.
  6. Vojtová, L. Léčba defektů kostí a chrupavek resorbovatelnými implantáty připravenými metodou Tkáňového inženýrství. 21. KOLOKVIUM, Sborník přednášek, ÚMCH AVČR Praha, MSD. 2012. (přednáška)
  7. Vojtová, L.; Jančář, J.; Nečas, A.; Srnec, R.; Plánka, L.; Prosecká, E.; Plecner, M.; Almer, E.; Křen, L., Hlučilová, J. Resorbable Implants For Hard Tissue Regeneration. CHEMICKÉ LISTY. Praha: Česká společnost chemická, 2011. s. s918 (s919 s.)ISSN: 1213- 7103.(přednáška)